High-Protein Pizza Breakfast Casserole

Featured in: Weekend Feast Ideas

This satisfying morning bake combines the classic flavors of pizza with a nutritious start to your day. A simple Greek yogurt dough forms the base, topped with pizza sauce, a creamy egg mixture, turkey pepperoni, and plenty of melted mozzarella and cheddar. Each serving delivers 20 grams of protein, making it an excellent choice for busy weekdays or meal prep Sundays. The dish comes together in just 45 minutes and can even be assembled the night before for effortless morning baking.

Updated on Sat, 07 Feb 2026 23:48:47 GMT
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese, turkey pepperoni, and bell peppers on a sheet pan. Save
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese, turkey pepperoni, and bell peppers on a sheet pan. | smokyfeast.com

This High-Protein Pizza Breakfast Casserole is a game-changing dish that combines the savory comfort of pizza with a nutritious, protein-packed start to your day. Featuring a simple Greek yogurt dough and loaded with eggs, turkey pepperoni, and melted cheese, it is an ideal solution for meal prep enthusiasts looking for a hearty and satisfying breakfast.

Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese, turkey pepperoni, and bell peppers on a sheet pan. Save
Freshly baked High-Protein Pizza Breakfast Casserole with golden bubbly cheese, turkey pepperoni, and bell peppers on a sheet pan. | smokyfeast.com

The secret to this casserole is the protein-rich base, which provides a chewy and flavorful crust without the heavy calories of traditional dough. When topped with a fluffy egg mixture and plenty of mozzarella and cheddar, every bite delivers a perfect balance of textures and savory pizza notes.

Ingredients

  • Greek Yogurt Dough:
  • 1 cup (245 g) plain Greek yogurt (2% or 0% fat)
  • 1 cup (120 g) self-rising flour (plus extra for dusting)
  • 1/2 tsp garlic powder
  • 1/2 tsp dried oregano
  • 1/4 tsp salt
  • Toppings:
  • 6 large eggs
  • 1/2 cup (120 ml) low-fat milk
  • 1 cup (110 g) shredded mozzarella cheese, part-skim
  • 1/2 cup (50 g) shredded cheddar cheese
  • 1/2 cup (40 g) turkey pepperoni slices
  • 1/2 cup (125 ml) pizza sauce (low-sugar, if preferred)
  • 1/4 cup (25 g) diced bell pepper (optional)
  • 1/4 cup (25 g) diced red onion (optional)
  • 1 tbsp chopped fresh basil or parsley (optional, for garnish)
  • Salt and black pepper, to taste
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Instructions

1. Oven Prep
Preheat oven to 400°F (200°C). Lightly grease or line a rimmed sheet pan (approx. 9x13 inches) with parchment paper.
2. Prepare Dough
In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms. Knead briefly on a lightly floured surface until smooth, about 2–3 minutes.
3. Shape Crust
Roll or press dough into a rectangle to fit your prepared sheet pan. Transfer dough to pan and press evenly to the edges.
4. Add Sauce
Spread pizza sauce evenly over the dough base.
5. Whisk Eggs
In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined.
6. First Cheese Layer
Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce.
7. Add Egg Mixture
Pour the egg mixture evenly over the cheese.
8. Final Toppings
Top with turkey pepperoni, remaining cheese, and optional bell pepper and red onion.
9. Bake
Bake for 22–25 minutes, or until the eggs are set and cheese is golden and bubbly.
10. Rest and Serve
Remove from oven. Let cool for 5 minutes, then garnish with fresh basil or parsley if desired. Slice and serve warm.

Zusatztipps für die Zubereitung

For the best results with the dough, ensure you knead it until it is smooth and no longer sticky. Using parchment paper is highly recommended as it prevents the crust from sticking to the sheet pan and makes it much easier to slice and serve once the eggs have set.

Varianten und Anpassungen

If you prefer a spicier breakfast, try adding red pepper flakes to the egg mixture or swapping the turkey pepperoni for spicy turkey sausage. For those who do not have self-rising flour, you can substitute it by mixing 1 cup of all-purpose flour with 1 1/2 teaspoons of baking powder and 1/4 teaspoon of salt.

Serviervorschläge

This versatile casserole can be prepped the night before and baked in the morning for maximum convenience. It pairs beautifully with a simple green salad or a side of fresh seasonal fruit. For an extra pizza-style experience, serve it with a small dish of warm marinara sauce on the side for dipping.

Sliced High-Protein Pizza Breakfast Casserole served warm, showcasing fluffy eggs, mozzarella, and a Greek yogurt dough crust. Save
Sliced High-Protein Pizza Breakfast Casserole served warm, showcasing fluffy eggs, mozzarella, and a Greek yogurt dough crust. | smokyfeast.com

Enjoy this High-Protein Pizza Breakfast Casserole as a delicious, 270-calorie meal that doesn't compromise on flavor. Whether you are serving a crowd or prepping for the week ahead, it’s a reliable and nutritious recipe that will quickly become a household favorite.

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Kitchen Questions

Can I make this ahead of time?

Yes, assemble the entire dish the night before and refrigerate. When ready to serve, bake as directed, adding a few extra minutes if needed since it will be cold.

What makes the crust different from regular dough?

The crust uses Greek yogurt combined with self-rising flour, creating a lighter, protein-rich base that's quicker to prepare than traditional yeast dough and requires no rising time.

Can I freeze leftovers?

Absolutely. Cut into individual portions, wrap tightly, and freeze for up to 3 months. Reheat in the microwave or oven until warmed through.

How do I make this vegetarian?

Simply omit the turkey pepperoni or replace it with vegetables like mushrooms, spinach, or bell peppers. The protein content will decrease slightly.

What can I serve with this?

A simple green salad or fresh fruit on the side balances the richness. For extra protein, add a side of turkey bacon or breakfast sausage links.

Can I use regular flour instead of self-rising?

Yes. Replace each cup of self-rising flour with 1 cup all-purpose flour mixed with 1 1/2 teaspoons baking powder and 1/4 teaspoon salt.

High-Protein Pizza Breakfast Casserole

Hearty breakfast bake with Greek yogurt crust, eggs, pepperoni and cheese. Perfect for meal prep.

Prep duration
20 min
Heat time
25 min
Complete duration
45 min
Created by Jackson Reed


Skill Level Easy

Heritage American

Output 6 Portions

Nutrition Labels None specified

What You'll Need

Greek Yogurt Dough

01 1 cup plain Greek yogurt (2% or 0% fat)
02 1 cup self-rising flour, plus extra for dusting
03 1/2 teaspoon garlic powder
04 1/2 teaspoon dried oregano
05 1/4 teaspoon salt

Toppings

01 6 large eggs
02 1/2 cup low-fat milk
03 1 cup shredded part-skim mozzarella cheese
04 1/2 cup shredded cheddar cheese
05 1/2 cup turkey pepperoni slices
06 1/2 cup low-sugar pizza sauce
07 1/4 cup diced bell pepper, optional
08 1/4 cup diced red onion, optional
09 1 tablespoon chopped fresh basil or parsley, optional
10 Salt and black pepper to taste

Method

Phase 01

Prepare baking surface: Preheat oven to 400°F. Lightly grease or line a 9x13-inch rimmed sheet pan with parchment paper.

Phase 02

Mix dough base: In a medium bowl, combine Greek yogurt, self-rising flour, garlic powder, oregano, and salt. Mix until a shaggy dough forms.

Phase 03

Knead and shape dough: Knead dough briefly on a lightly floured surface until smooth, approximately 2 to 3 minutes. Roll or press dough into a rectangle to fit the prepared sheet pan. Transfer to pan and press evenly to the edges.

Phase 04

Apply sauce: Spread pizza sauce evenly over the dough base.

Phase 05

Prepare egg mixture: In a large bowl, whisk together eggs, milk, a pinch of salt, and black pepper until well combined.

Phase 06

Layer cheese: Sprinkle half of the mozzarella and cheddar cheese over the pizza sauce.

Phase 07

Pour egg mixture: Pour the egg mixture evenly over the cheese layer.

Phase 08

Add toppings: Top with turkey pepperoni, remaining cheese, bell pepper, and red onion if using.

Phase 09

Bake casserole: Bake for 22 to 25 minutes, or until the eggs are set and cheese is golden and bubbly.

Phase 10

Cool and serve: Remove from oven and let cool for 5 minutes. Garnish with fresh basil or parsley if desired. Slice and serve warm.

Kitchen Tools

  • Mixing bowls
  • Whisk
  • Rolling pin
  • 9x13-inch sheet pan
  • Parchment paper
  • Knife and cutting board

Allergy Details

Always review ingredients for potential allergens and seek professional medical guidance if unsure.
  • Contains wheat and gluten
  • Contains eggs
  • Contains milk and dairy
  • Check pepperoni, cheese, and pizza sauce labels for additional allergens or additives.

Nutrition Details (per portion)

Values shown are estimates only - please consult healthcare providers for specific advice.
  • Energy: 270
  • Fats: 12 g
  • Carbohydrates: 20 g
  • Proteins: 20 g